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With the increasing use of parathyroid hormone therapy in patients with hypoparathyroidism, physicians need to closely monitor urinary citrate levels which, if too low, may result in calcium deposits and kidney stones, according to researchers. Their study, “Hypocitraturia is an Untoward Side Effect of Synthetic Human Parathyroid Hormone…

Diagnoses other than epilepsy, including hypoparathyroidism, should be considered when a patient arrives at the emergency room with seizures, according to a new case study. The report, “Hypoparathyroidism Causing Seizures: When Epilepsy Does Not Fit,” was published in Case Reports in Medicine. Adult-onset seizures are not an uncommon…

Long-term treatment with the human recombinant parathyroid hormone (rhPTH) in patients with hypoparathyrodism causes significant and sustained changes in bone remodeling and structural changes to the bone, according to researchers. Their study, “The Effects of Long-term Administration of rhPTH(1-84) in Hypoparathyroidism by Bone Histomorphometry,” was published in the Journal of…

A new, small, orally available compound has the potential to regulate abnormal calcium levels often seen in patients with hypoparathyroidism, according to preclinical research. The study, “Development of a Novel Human Parathyroid Hormone Receptor 1 (hPTHR1) Agonist (CH5447240), a Potent and Orally Available Small-Molecule for Treatment of Hypoparathyroidism,” was published…

The U.S. Food and Drug Administration has granted orphan drug designation to TransCon PTH, an investigative therapy by Ascendis Pharma to treat hypoparathyroidism. Hypoparathyroidism is a rare endocrine disorder characterized by insufficient levels of parathyroid hormone (PTH), resulting in low calcium and elevated phosphate levels in the blood. TransCon…

Treatment with the injectable parathyroid hormone Natpara slows the decline in kidney function in patients with chronic hypoparathyroidism, according to recent clinical trial data. Natpara, developed by Shire, is a recombinant human parathyroid hormone (rhPTH[1-84]) approved as an add-on to the conventional treatment of chronic hypoparathyroidism with calcium and activated…

Atypical kidney lesions in adult patients may be caused by a mutation associated with a rare type of  hypoparathyroidism, according to a case report. The study,“Unusual Proliferative Glomerulonephritis in a Patient Diagnosed to Have Hypoparathyroidism, Sensorineural Deafness, and Renal Dysplasia (HDR) Syndrome with…

As President Trump signed the recently passed Right to Try legislation into law in a White House ceremony, Jordan McLinn of Indianapolis tried twice to embrace him. The third time, 9-year-old Jordan finally got the hug he wanted — as well as a kiss on the forehead. The video of…

Screening for asymptomatic hypoparathyroidism should be considered in transfusion-dependent thalassemia patients to allow for early disease detection and intervention, researchers suggest. Their study, “Under-recognized Hypoparathyroidism in Thalassemia,” was published in the Journal of Clinical Research in Pediatric Endocrinology. The occurrence of asymptomatic hypoparathyroidism, defined as low levels…

Finding treatments and potential cures for rare diseases is crucial, but so is the quality of patients’ lives — a rather nebulous term that means different things to different people. “Recently, there’s been much more of a focus on Quality of Life (QoL) issues, real-world evidence and patient-reported outcomes,” said…