Men with chronic hypoparathyroidism may be more likely to develop chronic kidney disease (CKD), while women with the disorder may face higher risks of bone fractures, anxiety, and cognitive problems, according to a review study. Researchers also found that menopause, disease duration, and the underlying cause of hypoparathyroidism…
News
Children with hypoparathyroidism that is not a consequence of surgery may face a significant risk of kidney complications later in life, particularly calcium deposits and reduced function, but careful control of calcium and phosphate levels during treatment may help lower that risk, a long-term study in China found. The…
Accidental removal of the parathyroid glands during thyroid surgery has become less common — decreasing by about 35% from 2021 to 2023 — likely reflecting better surgical awareness and imaging tools such as near-infrared autofluorescence, according to a study in the U.K. But inadvertent removal is still common, occurring in nearly…
The first participants have been dosed in a Phase 1 clinical trial that Septerna is conducting to test SEP-479, its experimental oral treatment for hypoparathyroidism. The Phase 1 study is testing single and multiple doses of SEP-479 in up to 150 healthy volunteers, with the main goal of…
Single doses of canvuparatide, an injectable hormone replacement treatment being developed by MBX Biosciences for chronic hypoparathyroidism, appeared to be safe in healthy adults and were long-acting in the bloodstream, supporting the once-weekly dosing regimen now being tested in later-stage trials. These data come from the first…
MBX Biosciences is advancing its experimental therapy canvuparatide (MBX 2109) toward a Phase 3 trial in adults with chronic hypoparathyroidism, following a successful End-of-Phase 2 meeting with the U.S. Food and Drug Administration (FDA). An End-of-Phase 2 meeting is typically held after a Phase 2 study to determine whether a…
Taking calcium and vitamin D supplements as a preventive approach after thyroidectomy, or surgical removal of the thyroid, was found to lower the risk of transient hypoparathyroidism — a temporary condition marked by low blood calcium and low parathyroid hormone (PTH) levels — and to shorten patient hospital stays for…
A 27-year-old woman’s “silent” calcium deficiency due to hypoparathyroidism during pregnancy led to the surprise diagnosis of DiGeorge syndrome, a genetic disorder that had gone undetected for nearly three decades. Despite having no physical symptoms of low calcium, the woman’s persistent blood test results allowed doctors to catch the…
Entera Bio and Opko Health are teaming up to develop a once-daily oral treatment for hypoparathyroidism, known as a long-acting parathyroid hormone analog (LA-PTH). “Preclinical data of oral LA-PTH suggests that this program holds the potential to transform the hypoparathyroidism landscape,” Miranda Toledano, CEO of Entera, said…
Hypoparathyroidism was found to be the cause of unexplained leg pain for an 11-year-old girl, highlighting the importance of testing for the rare disorder in children with unexplained muscle pain, according to a case report. The case was discussed in the paper, “Eleven-Year-Old Girl With Bilateral…
Recent Posts
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