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Hypoparathyroidism Not Always Seen in APS1, Case Study Suggests

Impaired activity of the adrenal glands, a condition called Addison’s disease, may be the only typical manifestation of autoimmune polyglandular syndrome type 1 (APS1) to have occurred decades after diagnosis, a case report suggests. APS1, a rare inherited autoimmune disorder, is typically characterized by at least two of three manifestations:…

CASR Mutation Found as Cause of Patient’s Low Calcium Levels

A 13-year-old boy with autosomal dominant hypocalcemia (ADH) — a genetic form of hypoparathyroidism characterized by low calcium — who was unresponsive to conventional therapies was successfully treated with recombinant parathyroid hormone (rhPTH), according to a case report. rhPTH is a synthetic parathyroid hormone that can help regulate calcium…

Thyroid Surgery in Children Carries Risk of Hypoparathyroidism

Children with thyroid cancer or disease who undergo surgery to remove that gland can commonly have their parathyroid glands accidentally removed during the thyroidectomy, a U.S. study reports. While such surgeries are rare in children, this finding calls for meticulous attention from surgeons performing a thyroidectomy — especially if examining…