News

TransCon PTH treatment continues to show benefits for up to a year in people with hypoparathyroidism, helping them achieve normal blood calcium levels and reducing the need for conventional therapy. That’s according to new data from PATHway (NCT04701203), a Phase 3 clinical trial wherein Ascendis Pharma…

A natural history study of hypoparathyroidism taking place at Columbia University Irving Medical Center in New York has started to enroll adult patients. The study, called SHINE (NCT05793853), is recruiting an estimated 94 people, ages 18 and older, with any hypoparathyroidism subtype and undergoing any type of treatment…

Ascendis Pharma will request to meet with the U.S. Food and Drug Administration (FDA) in an effort to gain approval of TransCon PTH, its experimental hormone replacement therapy for hypoparathyroidism. “Based on our clinical experience with TransCon PTH to date, we have seen the improvement in the…

Using near-infrared autofluorescence (NIRAF) to protect the parathyroid glands during thyroid surgery did not significantly lower the risk of hypoparathyroidism as a surgical complication, a study with experienced thyroid surgeons reported. Although there were fewer hypoparathyroidism cases with NIRAF three months after surgery, differences  were not statistically significant when compared…

People with autoimmune hypoparathyroidism who have anti-CaSR antibodies — which play a role in regulating the parathyroid hormone, known as PTH — may benefit from adding steroid therapy to standard vitamin D and calcium supplementation, a case report suggests. That report described a 55-year-old woman who’d had seizures for 35…

About one in five people with Graves’ disease who undergo a thyroidectomy, which is the surgical removal of all or part of the thyroid gland, develop hypoparathyroidism, but most recover in less than six months. That’s according to a study looking back at the medical records of 216 people…

Using an imaging technique called near-infrared autofluorescence (NIRAF) during thyroid surgery can help to lower the risk of hypoparathyroidism as a surgery complication, a study reported, detailing a workable approach for its use. The study, “Prevention of hypoparathyroidism: A step-by-step near-infrared autofluorescence parathyroid identification method,” was…

Mutations in the CYP24A1 gene were identified as a cause of a 43-year-old man’s idiopathic infantile hypercalcemia (IIH), a condition marked by higher than normal blood calcium levels. The man also had low levels of parathyroid hormone (PTH), a sign of hypoparathyroidism, and normal vitamin D —  unusual for…

The use of calcium and vitamin D supplements to compensate for the low levels of parathyroid hormone (PTH) in hypoparathyroidism is not impeded by the abnormal vitamin D metabolism caused by the rare disease, a study reports. People with hypoparathyroidism had higher levels of 25(OH)D, a marker of vitamin…

Two severe cases of hypoparathyroidism were associated with two newly identified mutations in the glial cell missing homolog 2 (GCM2) gene by scientists in India. “This report demonstrates the critical role of GCM2 activity in human parathyroid gland development through clinical and genetic analysis of 2 patients with hypoparathyroidism,” the…