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Biotech company Septerna is currently conducting preclinical tests to identify a lead experimental therapy for hypoparathyroidism, with the hope of starting clinical trials in 2026. “We are executing effectively across our portfolio, with each program nearing important milestones,” Jeffrey Finer, MD, PhD, CEO and co-founder of Septerna, said…

Technology used in real time may help surgeons identify a greater number of parathyroid glands during surgery — including in patients undergoing thyroidectomy, a procedure to remove part or all of the thyroid gland that is a common cause of hypoparathyroidism. That’s according to a new study that detailed…

Autotransplanting parathyroid glands to a muscle of the neck after surgery to remove the thyroid gland is tied to a higher risk of transient hypoparathyroidism, but progresses to permanent hypoparathyroidism less often, a study in China suggests. The risk of permanent hypoparathyroidism, that is, that which lasts more than…

The risk of fractures in the vertebrae, the bones in the spine, was 55% higher in people with chronic hypoparathyroidism than in the general population, a nationwide study in Sweden found. Conversely, the risk of femur (thighbone) fractures was 30% less common in the hypoparathyroidism group. Chronic hypoparathyroidism patients…

Women who develop hypoparathyroidism after surgery often have problems with bladder control, both on tests and in daily life, a small study found. The researchers recommended that checking urinary symptoms and bladder emptying be part of routine follow-up. The study, “Hypoparathyroidism is associated with bladder dysfunction, a preliminary…

Women, Hispanic patients, people who have other health problems, and those who have more lymph nodes removed are at higher risk of emergency visits for hypoparathyroidism after thyroid surgery, a study found. “Most risk factors identified are not modifiable, but they help identify high-risk patients who could benefit from…

Treatment with the investigational therapy encaleret normalized calcium levels for most people with chronic hypoparathyroidism in a small proof-of-principle study. That’s according to data announced by Bridgebio Pharma, which is developing encaleret with its affiliate Calcilytix Therapeutics. The company said it hopes to launch a clinical trial…

People with long-lasting hypoparathyroidism after thyroid surgery are at risk of having deteriorating kidney function, according to a study from Spain. “This study demonstrated that patients were at greater risk of chronic kidney disease, progression to end-stage kidney disease, and faster decline in [kidney function] compared to subjects without…

Postmenopausal women and men over age 50 with chronic hypoparathyroidism showed signs of significant bone fragility, with a high proportion of fractures and osteoporosis, according to a study that calls for a closer follow-up of patients’ skeletal health. The study, “Skeletal health status among patients with…

Hypoparathyroidism is often temporary in children who undergo surgical removal of the thyroid, or thyroidectomy, with most recovering normal parathyroid function within six months, a study in China shows. The time needed to recover from hypoparathyroidism was found to be closely related to the levels of parathyroid hormone (PTH)…