Three months of once-weekly canvuparatide (MBX 2109) normalized blood calcium levels in most adults with chronic hypoparathyroidism, without the need for standard supplement therapy. That’s according to top-line data from a Phase 2 trial called Avail (NCT06465108), which enrolled 64 adults with chronic hypoparathyroidism who had been…
Treatment with Encaleret led to rapid normalization of both blood and urine calcium levels in a Phase 2 study involving people with chronic hypoparathyroidism. Within five days of treatment initiation, 80% of participants achieved normal calcium levels, whereas none had achieved such levels with conventional therapy at the…
People who develop chronic hypoparathyroidism following surgery are at high risk of kidney problems and infections, and they also tend to rack up hundreds of thousands of dollars in healthcare costs. That’s according to two studies led by scientists at Ascendis Pharma, both published in Advances in Therapy.
Biotech company Septerna is currently conducting preclinical tests to identify a lead experimental therapy for hypoparathyroidism, with the hope of starting clinical trials in 2026. “We are executing effectively across our portfolio, with each program nearing important milestones,” Jeffrey Finer, MD, PhD, CEO and co-founder of Septerna, said…
Technology used in real time may help surgeons identify a greater number of parathyroid glands during surgery — including in patients undergoing thyroidectomy, a procedure to remove part or all of the thyroid gland that is a common cause of hypoparathyroidism. That’s according to a new study that detailed…
Autotransplanting parathyroid glands to a muscle of the neck after surgery to remove the thyroid gland is tied to a higher risk of transient hypoparathyroidism, but progresses to permanent hypoparathyroidism less often, a study in China suggests. The risk of permanent hypoparathyroidism, that is, that which lasts more than…
The risk of fractures in the vertebrae, the bones in the spine, was 55% higher in people with chronic hypoparathyroidism than in the general population, a nationwide study in Sweden found. Conversely, the risk of femur (thighbone) fractures was 30% less common in the hypoparathyroidism group. Chronic hypoparathyroidism patients…
Women who develop hypoparathyroidism after surgery often have problems with bladder control, both on tests and in daily life, a small study found. The researchers recommended that checking urinary symptoms and bladder emptying be part of routine follow-up. The study, “Hypoparathyroidism is associated with bladder dysfunction, a preliminary…
Women, Hispanic patients, people who have other health problems, and those who have more lymph nodes removed are at higher risk of emergency visits for hypoparathyroidism after thyroid surgery, a study found. “Most risk factors identified are not modifiable, but they help identify high-risk patients who could benefit from…
Treatment with the investigational therapy encaleret normalized calcium levels for most people with chronic hypoparathyroidism in a small proof-of-principle study. That’s according to data announced by Bridgebio Pharma, which is developing encaleret with its affiliate Calcilytix Therapeutics. The company said it hopes to launch a clinical trial…
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