Vanda Pinto, PhD, science writer —

A Phase 1 clinical trial evaluating the safety and pharmacological properties of MBX 2109 — MBX Biosciences’ investigational hormone replacement therapy for people with hypoparathyroidism — in healthy volunteers has moved to its second part. This portion, which will test multiple MBX 2109 doses, follows the successful completion…

The dual transplant of a kidney and a parathyroid gland was safe and effective at restoring parathyroid hormone (PTH) levels and turning back kidney disease, in an 11-year-old girl with congenital hypoparathyroidism and renal failure, a case study reports. “Simultaneous living donation and transplantation of a kidney and a…

Vitamin D levels can accurately predict reductions in parathyroid hormone (PTH) following thyroidectomy in patients with papillary thyroid cancer (PTC), a study reports. Its researchers recommend vitamin D supplements before surgery to minimize the drop in PTH levels in patients with PTC who have vitamin D deficiency. The study, “…

In a woman whose severe hypoparathyroidism did not respond to standard treatment, constant infusion of a lab-engineered form of the parathyroid hormone (PTH) eliminated symptoms and improved her quality of life, a case study from Portugal reports. This medication, called Forsteo (teriparatide) and marketed in the U.S. as…

Four new mutations of the AIRE gene were identified for the first time in Chinese patients with autoimmune polyendocrine syndrome type 1 (APS1), a case series reports. The report also presents a thorough evaluation of the clinical and genetic characteristics of Chinese APS1 patients and some rarely observed symptoms.