Marisa Wexler, MS, senior science writer —

Ascendis Pharma‘s TransCon PTH can safely treat hypoparathyroidism, reducing the need for other therapies and improving patients’ quality of life, an extension period of the PaTH Forward Phase 2 trial shows. “Today we announced preliminary clinical results which demonstrate that TransCon PTH can potentially…

TransCon PTH, an investigational therapy being developed by Ascendis Pharma, safely normalized calcium and phosphate levels, and reduced the need for other treatments in adults with hypoparathyroidism, data from the PaTH Forward Phase 2 trial demonstrate. The data were presented by Ascendis…

A novel approach for the production of parathyroid-like cells from stem cells — cells from which all others with specialized functions are generated — could help find new treatments for hypoparathyroidism, a study suggests. The study, “Differentiation of parathyroid hormone expressing cells from human pluripotent…

ProLynx has been awarded a small business innovation research grant from the National Institutes of Health (NIH) to develop its long-acting parathyroid hormone (PTH) therapy — known as PTH(1-34) — for people with hypoparathyroidism. Hypoparathyroidism is an uncommon condition characterized by low levels of PTH,…

Alizé Pharma 3 is rebranding as Amolyt Pharma and plans to start clinical testing of a potential hypoparathyroidism treatment known as AZP-3601 later this year. “Our new name, Amolyt Pharma, is derived from ammolite, a rare gemstone originating from living organisms,” Thierry Abribat, PhD, the company’s founder and…

People with hypoparathyroidism may be at risk of having calcium crystals form in their tendons — a condition called calcific tendonitis — which can cause joint pain and inflammation, a new case report suggests. The report, “Acute calcific epicondylitis associated with primary hypoparathyroidism: a paradox effect…

People needing to take vitamin D and calcium supplements due to very low levels soon after thyroid cancer surgery are likely to experience a decline in their quality of life (QOL) over at least the following year, a study suggests. As such, assessing calcium and vitamin D levels, as well…

People with hypoparathyroidism after surgical removal of the thyroid may develop calcium-alkali syndrome (CAS) — particularly if they are given high doses of vitamin D as a part of post-surgical care, a new study suggests. These findings highlight a need for routine surveillance of calcium levels following thyroid…

Lower levels of parathyroid hormone (PTH) in people with hypoparathyroidism may lead to decreased bone material strength and increase the risk of fractures, a new study reports. The study, “PTH and bone material strength in hypoparathyroidism as measured by impact microindentation,” was published in the journal…

A Phase 2 trial testing the experimental therapy TransCon PTH in adults with hypoparathyroidism is expanding to allow for faster enrollment of people previously treated with Natpara (parathyroid hormone, PTH), which was recently recalled in the United States. Developed by Ascendis Pharma, TransCon PTH is intended to restore…